Open AccessThe -174 G>C Interleukin-6 Gene Polymorphism is Associated with Angiographic Progression of Coronary Artery Disease over a 4-Year Period
Author(s) -
Konstantinos Toutouzas,
Dimitrios Klettas,
Nikolaos AnousakisVlachochristou,
Konstantinos Melidis,
Zeta Azilazian,
Maria Asimomiti,
Αντώνιος Καρανάσος,
Anastasios Spanos,
Eleftherios Tsiamis,
Petros Nihoyannopoulos,
Dimitris Tousoulis
Publication year - 2017
Publication title -
hellenic journal of cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.513
H-Index - 19
eISSN - 2241-5955
pISSN - 1109-9666
DOI - 10.1016/j.hjc.2017.02.002
Subject(s) - medicine , coronary artery disease , cardiology , period (music) , interleukin 1β , disease , gene , interleukin , gastroenterology , genetics , cytokine , biology , physics , acoustics
Inflammation is a key process underlying the clinical course of coronary artery disease (CAD). C-reactive protein (CRP) and interleukin-6 (IL-6) contribute to its pathophysiology and act as biomarkers. We sought to examine whether known single nucleotide polymorphisms (SNPs) impact CAD progression, reflecting increased inflammation.
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