Senile cardiac amyloidosis: Clinical manifestations and non-invasive diagnostic approach

Cardiac amyloidosis (CA) refers to a rare metabolic storage disease with poor prognosis that relies on identification of the amyloid type. In our aging population, wild-type transthyretin amyloidosis (ATTRwt), also known as senile cardiac amyloidosis (SCA), is more common and must be differentiated from other amyloid types. We present a case of SCA diagnosed in a patient with signs and symptoms of congestive heart failure and discuss the clinical features, imaging study findings and the key “red flags” a clinician should evaluate to avoid underdiagnosis of SCA.