Biomarkers for Primary Sjögren’s Syndrome | Zendy

Weiqian Chen | Zendy; Heng Cao | Zendy; Jin Lin | Zendy; Nancy J. Olsen | Zendy; Song Guo Zheng | Zendy

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Biomarkers for Primary Sjögren’s Syndrome

Author(s) -

Weiqian Chen,

Heng Cao,

Jin Lin,

Nancy J. Olsen,

Song Guo Zheng

Publication year - 2015

Publication title -

genomics proteomics and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.114

H-Index - 49

eISSN - 2210-3244

pISSN - 1672-0229

DOI - 10.1016/j.gpb.2015.06.002

Subject(s) - biomarker , medicine , disease , diagnostic biomarker , biomarker discovery , autoimmune disease , saliva , pathogenesis , exocrine gland , systemic disease , immunology , pathology , biology , diagnostic accuracy , proteomics , gene , biochemistry , secretion

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjögren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.

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