Open AccessThe Campylobacter jejuni glycome
Author(s) -
Karlyshev Andrey V.,
Ketley Julian M.,
Wren Brendan W.
Publication year - 2005
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1016/j.fmrre.2005.01.003
Subject(s) - campylobacter jejuni , glycome , biology , glycan , campylobacter , glycoprotein , glycomics , microbiology and biotechnology , glycosylation , genetics , bacteria
Microbial cell surface glycans in the form of glycolipids and glycoproteins frequently play important roles in cell–cell interaction and host immune responses. Given the likely importance of these surface structures in the survival and pathogenesis of Campylobacter jejuni , a concerted effort has been made to characterise these determinants genetically and structurally since the genome was sequenced in 2000. We review the considerable progress made in characterising the Campylobacter glycome including the lipooligosaccharide (LOS), the capsule and O ‐ and N ‐linked protein glycosylation systems, and speculate on the roles played by glycan surface structures in the life‐cycle of C. jejuni.