Open AccessStreptococcus rattus strain BHT produces both a class I two‐component lantibiotic and a class II bacteriocin
Author(s) -
Hyink Otto,
Balakrishnan Mayooran,
Tagg John R.
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.09.003
Subject(s) - lantibiotics , bacteriocin , microbiology and biotechnology , strain (injury) , streptococcaceae , component (thermodynamics) , biology , streptococcus , class (philosophy) , chemistry , bacteria , genetics , antibiotics , antimicrobial , physics , philosophy , anatomy , thermodynamics , epistemology
Streptococcus rattus strain BHT is a species representative and strong bacteriocin producer. Here we report that S. rattus BHT produces two quite different types of bacteriocin activity, named BHT‐A and BHT‐B. The two bacteriocins were purified and analysed for activity and by MALDI‐TOF mass spectrophotometry. BHT‐A was found to be a variant of the two‐component lantibiotic, Smb. BHT‐B is a non‐modified 5195 Da peptide with some similarity to the tryptophan‐rich Staphylococcus aureus bacteriocin, aureocin A53. Six S. rattus and two S. mutans strains were found to contain both the BHT‐A and BHT‐B genetic loci.