Open AccessCytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp.
Author(s) -
Lin Xin,
Huang Yaojian,
Fang Meijuan,
Wang Jianfeng,
Zheng Zhonghui,
Su Wenjin
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.07.025
Subject(s) - kandelia candel , antimicrobial , fungus , biology , mangrove , botany , microbiology and biotechnology , ecology
A new compound ( 1 ), named diaporthelactone, together with two known compounds ( 2 and 3 ) were isolated from the culture of Diaporthe sp., a marine fungus growing in the submerged rotten leaves of Kandelia candel in the mangrove nature conservation areas of Fugong, Fujian Province of China. The new compound was elucidated to be 1,3‐dihydro‐4‐methoxy‐7‐methyl‐3‐oxo‐5‐isobenzofuran‐carboxyaldehyde ( 1 ), which showed cytotoxic activity against KB and Raji cell lines (IC 50 6.25 and 5.51 μg mL −1 , respectively). Two known compounds, 7‐methoxy‐4,6‐dimethyl‐3 H ‐isobenzofuran‐1‐one ( 2 ) and mycoepoxydiene ( 3 ), were also demonstrated to exhibit cytotoxic activities for the first time. All three compounds were assessed for antimicrobial activity.