Open AccessStaphylococcal Drp35 is the functional counterpart of the eukaryotic PONs
Author(s) -
Morikawa Kazuya,
Hidaka Toshie,
Murakami Hiroyuki,
Hayashi Hideo,
Ohta Toshiko
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.06.038
Subject(s) - inducer , bacitracin , antibiotics , staphylococcus aureus , microbiology and biotechnology , biology , staphylococcus , bacteria , chemistry , genetics , gene
Drp35 has been identified as a protein that is induced in Staphylococcus aureus in response to exposure to certain antibiotics. Here we demonstrate that Drp35 is a lactonase that does not contribute directly to the resistance to the inducer antibiotics except for bacitracin. The detailed analysis on the expression of Drp35 revealed that in addition to a broad range of antibiotics, agents such as detergents that perturb the membrane integrity could induce its expression. The significance of this characteristic expression is discussed in relation to its activity similarity to the eukaryotic counterparts, paraoxonase family proteins.