Open AccessIdentification of genetic markers for Mycobacterium pinnipedii through genome analysis
Author(s) -
Bigi Fabiana,
GarciaPelayo M. Carmen,
NuñezGarcía Javier,
Peralta Andrea,
Caimi Karina C.,
Golby Paul,
Hinds Jason,
Cataldi Angel,
Gordon Stephen V.,
Romano Maria I.
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.05.034
Subject(s) - mycobacterium tuberculosis , biology , mycobacterium tuberculosis complex , mycobacterium bovis , genetics , mycobacterium , gene , genome , identification (biology) , comparative genomics , tuberculosis , genomics , microbiology and biotechnology , bacteria , medicine , botany , pathology
Tuberculosis in seals is caused by Mycobacterium pinnipedii , a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray‐based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii : PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.