Open AccessCoating of a surface with 2‐methacryloyloxyethyl phosphorylcholine (MPC) co‐polymer significantly reduces retention of human pathogenic microorganisms
Author(s) -
Hirota Katsuhiko,
Murakami Keiji,
Nemoto Ken,
Miyake Yoichiro
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.05.019
Subject(s) - phosphorylcholine , superhydrophilicity , biofilm , microbiology and biotechnology , staphylococcus aureus , candida albicans , pseudomonas aeruginosa , streptococcus mutans , coating , microorganism , chemistry , bacteria , biology , materials science , wetting , biochemistry , composite material , organic chemistry , genetics
The present study compares the retention of four species that are often isolated in association with biomedical device‐related infections – Staphylococcus aureus , Streptococcus mutans , Pseudomonas aeruginosa , and Candida albicans – to three different surfaces. All four bacterial species were found to bind significantly less well to MPC‐coated surfaces than to non‐coated surfaces. We attribute this effect to the “superhydrophilicity” of MPC‐coated surfaces, whereas hydrophobic surfaces are well known to reduce bacterial retention and thus to inhibit a crucial step in the formation of bacterial biofilms that lead to biomedical device‐related infections and complications.