Open AccessADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus
Author(s) -
Lavens Sandra E.,
RoviraGraells Núria,
Birch Mike,
Tuckwell Danny
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2005.05.017
Subject(s) - aspergillus fumigatus , identification (biology) , aspergillus , microbiology and biotechnology , biology , gene , genetics , botany
The ADAMs are a family of integral membrane proteases involved in shedding and fusion events in animal tissues. Here, we report the identification of two ADAMs, ADM‐A and ADM‐B, in the pathogenic fungus Aspergillus fumigatus . The domain structure of metazoan ADAMs was seen in ADM‐A and ‐B, although with some differences. ADAMs were identified in other filamentous fungi and phylogenetic analysis indicated that the fungal ADAMs were monophyletic and most closely related to metazoan ADAM 10 and 17. Recombinant ADM‐B protease specifically cleaved casein and albumin while recombinant propeptide + protease was inactive. A sheddase function is therefore proposed for fungal ADAMs.