Open AccessA phosphatidyl‐inositol‐3‐kinase‐dependent anti‐inflammatory pathway activated by Salmonella in epithelial cells
Author(s) -
Huang FuChen,
Li Qian,
Cherayil Bobby J.
Publication year - 2005
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2004.12.013
Subject(s) - pi3k/akt/mtor pathway , salmonella , protein kinase b , microbiology and biotechnology , mapk/erk pathway , kinase , signal transduction , inositol , inflammation , chemistry , biology , biochemistry , bacteria , immunology , receptor , genetics
Abstract Salmonella activates the phosphatidyl‐inositol‐3‐kinase (PI3K)/Akt pathway in epithelial cells, but its role in inflammation has not been previously elucidated. We show here that inhibition of PI3K in T84 intestinal epithelial cells results in augmentation of Salmonella ‐induced interleukin‐8 (IL‐8) production at the level of both protein and mRNA. The mechanism of this effect appears to involve altered activation of the extracellular growth factor‐regulated kinase (ERK), a molecule that is implicated in the regulation of IL‐8 expression. These results identify activation of the PI3K/Akt pathway as an anti‐inflammatory signal that may contribute to the establishment of Salmonella in the intestine.