Open AccessHIV and the CCR5‐Δ32 resistance allele
Author(s) -
Silva Eric,
Stumpf Michael P.H.
Publication year - 2004
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/j.femsle.2004.09.040
Subject(s) - allele , biology , genetics , human immunodeficiency virus (hiv) , population genetics , population , resistance (ecology) , evolutionary biology , virology , gene , medicine , ecology , environmental health
The combination of molecular biology, epidemiology, virology, evolutionary and population genetics has enabled us to understand the delicate interplay between HIV and the CCR5‐Δ32 HIV resistance allele. We here review and collect from the different approaches to show how they can be combined to elucidate the interaction between host and pathogen genetics in this system. We will present an overview of the normal role of CCR5, its involvement in HIV, the molecular biology of the CCR5‐Δ32 allele and its probable origins. By focusing on this well‐documented and important system we hope to demonstrate the power that such a “holistic” approach might offer in the study of infectious diseases.