Cholesterol and the activity of bacterial toxins | Zendy

Matthew R. Palmer | Zendy

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Cholesterol and the activity of bacterial toxins

Author(s) -

Matthew R. Palmer

Publication year - 2004

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1016/j.femsle.2004.07.059

Subject(s) - vibrio cholerae , cytolysin , toxin , microbiology and biotechnology , microbial toxins , hemolysin , staphylococcus aureus , bacteria , cholesterol , biology , diphtheria toxin , cholera toxin , chemistry , biochemistry , virulence , genetics , gene

Cholesterol may affect the activity of microbial toxins in a direct, specific way, or it may exert indirect effects because of its role in membrane fluidity, membrane line tension, and in the stabilization of rafts in the cytoplasmic membrane. The thiol-activated toxins of gram-positive bacteria, and the cytolysin of Vibrio cholerae are presented as examples of specific toxin-cholesterol interaction. Several mechanisms of indirect effects of cholesterol are discussed using examples such as Staphylococcus aureus alpha-hemolysin, aerolysin, and diphtheria toxin.

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