The streptococcolytic enzyme zoocin A is a penicillin-binding protein | Zendy

Lucie S. Heath | Zendy; Harry E. Heath | Zendy; Paul A. LeBlanc | Zendy; S. Rochelle Smithberg | Zendy; Muriel Dufour | Zendy; Robin S. Simmonds | Zendy; Gary L. Sloan | Zendy

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The streptococcolytic enzyme zoocin A is a penicillin-binding protein

Author(s) -

Lucie S. Heath,

Harry E. Heath,

Paul A. LeBlanc,

S. Rochelle Smithberg,

Muriel Dufour,

Robin S. Simmonds,

Gary L. Sloan

Publication year - 2004

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1016/j.femsle.2004.05.038

Subject(s) - penicillin , microbiology and biotechnology , enzyme , chemistry , penicillin binding proteins , biochemistry , biology , antibiotics

Zoocin A is a streptococcolytic enzyme produced by Streptococcus equi subsp. zooepidemicus 4881 that has an unknown site of action on the peptidoglycans of susceptible organisms. Analysis of a mutant strain in which the genes for zoocin A and resistance to zoocin A were inactivated revealed that this strain was more susceptible to beta-lactam antibiotics than the parental organism. Purified zoocin A had weak beta-lactamase activity, bound radioactive penicillin covalently, and its streptococcolytic activity was inhibited by penicillin. Thus, zoocin A is a penicillin-binding protein and presumably is a D-alanyl endopeptidase.

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