Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex | Zendy

Kerry J. Glendinning | Zendy

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Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex

Author(s) -

Kerry J. Glendinning

Publication year - 2004

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1016/j.femsle.2004.04.039

Subject(s) - burkholderia cepacia complex , biology , burkholderia cenocepacia , gene cluster , gene , genetics , lineage (genetic) , microbiology and biotechnology , burkholderia , nucleic acid sequence , genome , bacteria , virulence

The Burkholderia cepacia complex (BCC) comprises a group of bacteria associated with opportunistic infections, especially in cystic fibrosis patients. B. cenocepacia J2315, of the transmissible ET12 lineage, contains a type III secretion (TTS) gene cluster implicated in pathogenicity. PCR and hybridisation assays indicate that the TTS gene cluster is present in all members of the BCC except B. cepacia (formerly genomovar I). The TTS gene clusters of B. cenocepacia J2315 and B. multivorans are similar in organisation but have variable levels of gene identity. Nucleotide sequence data obtained for the equivalent region of the B. cepacia genome indicate the absence of TTS structural genes due to a rearrangement likely to involve more than one step.

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