Diversity of genetic environment of blaCTX-M genes | Zendy

Marie Frédérique Lartigue | Zendy

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Diversity of genetic environment of blaCTX-M genes

Author(s) -

Marie Frédérique Lartigue

Publication year - 2004

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1016/j.femsle.2004.01.051

Subject(s) - gene , transposition (logic) , biology , insertion sequence , sequence (biology) , genetics , mobile genetic elements , microbiology and biotechnology , plasmid , genome , transposable element , philosophy , linguistics

Twenty-four non-clonally related enterobacterial isolates producing the emerging CTX-M-type extended-spectrum beta-lactamases were recovered from several countries including France, India, Poland, and Turkey. They had been isolated from 2000 to 2003. beta-Lactamases CTX-M-2, CTX-M-3, CTX-M-10, CTX-M-14 and CTX-M-15 were identified. Most of the isolates produced beta-lactamase CTX-M-15. Insertion sequence ISEcp1 was found upstream of bla(CTX-M-3), bla(CTX-M-10), bla(CTX-M-14) and bla(CTX-M-15) genes. A sequence similar to the inverted right repeat of ISEcp1 was identified downstream of bla(CTX-M-3), bla(CTX-M-10) and bla(CTX-M-15) genes suggesting the mobilization of these beta-lactamase genes by transposition events. In addition, Orf513 was identified upstream of the bla(CTX-M-2) gene. This work further underlined widespread of bla(CTX-M-15) gene associated with ISEcp1.

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