Open AccessManganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements
Author(s) -
Fréalle Emilie,
Noël Christophe,
Viscogliosi Eric,
Camus Daniel,
DeiCas Eduardo,
Delhaes Laurence
Publication year - 2005
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/j.femsim.2005.06.003
Subject(s) - biology , basidiomycota , cryptococcus neoformans , ascomycota , microbiology and biotechnology , fungal protein , pathogenic fungus , phylogenetics , superoxide dismutase , phylogenetic tree , yeast , fungus , botany , enzyme , genetics , gene , biochemistry , saccharomyces cerevisiae
Manganese‐containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts ( Cryptococcus neoformans var. grubii , Cryptococcus neoformans var. gattii , Malassezia sympodialis ), Ascomycota filamentous fungi ( Aspergillus fumigatus ), and Ascomycota yeasts ( Candida albicans ). MnSOD‐based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.