Combined detection of  Chlamydia trachomatis ‐specific antibodies against the 10 and 60‐kDa heat shock proteins as a diagnostic tool for tubal factor infertility: Results from a case‐control study in Cameroon | Zendy

Dadamessi Innocenti | Zendy; Eb François | Zendy; Betsou Fotini | Zendy

Open Access

Combined detection of Chlamydia trachomatis ‐specific antibodies against the 10 and 60‐kDa heat shock proteins as a diagnostic tool for tubal factor infertility: Results from a case‐control study in Cameroon

Author(s) -

Dadamessi Innocenti,

Eb François,

Betsou Fotini

Publication year - 2005

Publication title -

fems immunology & medical microbiology

Language(s) - English

Resource type - Journals

eISSN - 1574-695X

pISSN - 0928-8244

DOI - 10.1016/j.femsim.2005.01.009

Subject(s) - chlamydia trachomatis , chlamydiales , tubal factor infertility , chlamydiaceae , biology , antibody , infertility , heat shock protein , chlamydia , immunology , virology , pregnancy , genetics , gene

A case‐control study was conducted to determine the diagnostic value of Chlamydia trachomatis ‐associated anti‐Chsp10 and/or anti‐Chsp60 antibodies in the detection of secondary infertility. There were significant associations between C. trachomatis infection and infertility ( p < 0.01 ), and between C. trachomatis ‐specific anti‐Chsp10 or anti‐Chsp60 antibodies and secondary infertility ( p < 0.001 ). A significant correlation was found between anti‐Chsp10 and anti‐Chsp60 titers ( p < 0.01 ). The detection of either C. trachomatis ‐associated anti‐Chsp10 or anti‐Chsp60 antibodies cumulatively allowed specific diagnosis of secondary infertility (57.4% sensitivity, 75.5% specificity).

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