Open AccessCombined detection of Chlamydia trachomatis ‐specific antibodies against the 10 and 60‐kDa heat shock proteins as a diagnostic tool for tubal factor infertility: Results from a case‐control study in Cameroon
Author(s) -
Dadamessi Innocenti,
Eb François,
Betsou Fotini
Publication year - 2005
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/j.femsim.2005.01.009
Subject(s) - chlamydia trachomatis , chlamydiales , tubal factor infertility , chlamydiaceae , biology , antibody , infertility , heat shock protein , chlamydia , immunology , virology , pregnancy , genetics , gene
A case‐control study was conducted to determine the diagnostic value of Chlamydia trachomatis ‐associated anti‐Chsp10 and/or anti‐Chsp60 antibodies in the detection of secondary infertility. There were significant associations between C. trachomatis infection and infertility ( p < 0.01 ), and between C. trachomatis ‐specific anti‐Chsp10 or anti‐Chsp60 antibodies and secondary infertility ( p < 0.001 ). A significant correlation was found between anti‐Chsp10 and anti‐Chsp60 titers ( p < 0.01 ). The detection of either C. trachomatis ‐associated anti‐Chsp10 or anti‐Chsp60 antibodies cumulatively allowed specific diagnosis of secondary infertility (57.4% sensitivity, 75.5% specificity).