Open AccessMacrolide‐affected Toll‐like receptor 4 expression from Helicobacter pylori ‐infected monocytes does not modify interleukin‐8 production
Author(s) -
Park Joon Yong,
Kim Hak Yang,
Lee Ja Young,
Kim Kyung Ho,
Jang Myung Kook,
Lee Jin Heon,
Yoo Jae Young,
Han Dong Soo,
Hahm Joon Soo
Publication year - 2005
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/j.femsim.2005.01.007
Subject(s) - secretion , helicobacter pylori , lipopolysaccharide , biology , toll like receptor , microbiology and biotechnology , clarithromycin , receptor , inflammation , interleukin , immunology , interleukin 1 receptor , gastritis , antibiotics , cytokine , immune system , innate immune system , endocrinology , biochemistry , genetics
Macrolide antibiotics have an anti‐inflammatory effect by suppressing lipopolysaccharide‐induced IL‐8 production. IL‐8 secretion from monocytes is observed in Helicobacter pylori infection. Although cag gene products are known to induce IL‐8 secretion, whether other bacterial substances can initiate the reaction is not determined. In this study, we show that clarithromycin induced down‐regulation of Toll‐like receptor 4 expression and did not lead to a decrease in IL‐8 production and H. pylori lipopolysaccharide. However, Toll‐like receptor 4 activation was possibly not the main cause in the induction of inflammation during H. pylori infection.