Open AccessAltered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever
Author(s) -
Chen RongFu,
Liu JienWei,
Yeh WenTing,
Wang Lin,
Chang JenChieh,
Yu HongRen,
Cheng JiinTsuey,
Yang Kuender D.
Publication year - 2005
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/j.femsim.2004.11.012
Subject(s) - dengue fever , dengue virus , immunology , virology , pathogenesis , immune system , dengue hemorrhagic fever , virus , biology , outbreak , viral load
To investigate whether dengue‐2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T‐bet/GATA‐3 mRNA expression in a large outbreak of dengue‐2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN‐γ levels, but patients with dengue hemorrhagic fever had significantly higher IL‐10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T‐bet than those with dengue fever, but GATA‐3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T‐bet mRNA expression associated with higher IL‐10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.