Cibenzoline induced Brugada ECG pattern
Author(s) -
Andrea Sarkozy,
Axel Caenepeel,
P. Geelen,
P PEYTCHEV,
M DEZUTTER,
Pedro Brugada
Publication year - 2005
Publication title -
ep europace
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 102
eISSN - 1532-2092
pISSN - 1099-5129
DOI - 10.1016/j.eupc.2005.06.013
Subject(s) - medicine , ajmaline , brugada syndrome , cardiology , right bundle branch block , bundle branch block , palpitations , sodium channel blocker , st segment , electrocardiography , flecainide , discontinuation , st elevation , anesthesia , atrial fibrillation , sodium channel , myocardial infarction , chemistry , organic chemistry , sodium
We report a case of a 61-year-old female patient who presented with palpitations. The baseline electrocardiogram showed incomplete right bundle branch block with saddle back pattern of the ST segment in one precordial lead, but without any significant ST elevation. She was treated with oral cibenzoline. The subsequent ECG showed a coved Brugada ECG (type I) pattern, which resolved following the discontinuation of cibenzoline. An ajmaline test reproduced the coved type Brugada ECG pattern. Our case is the first report of oral cibenzoline therapy unmasking the diagnostic coved Brugada ECG pattern in a patient with a baseline normal ECG. Cibenzoline, a class I sodium channel blocker antiarrhythmic drug, should probably be avoided in the treatment of patients with Brugada syndrome.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom