Open AccessSerum levels of 25(OH) vitamin D and immunoglobulin E in infants with bronchiolitis
Author(s) -
Bahaa El Din Mohamed Hassanein,
Doaa Refaey Soliman,
Sahar Mohamed Fayed,
Mohamed Mosaad Mohamed Suleiman
Publication year - 2016
Publication title -
egyptian pediatric association gazette
Language(s) - English
Resource type - Journals
eISSN - 2090-9942
pISSN - 1110-6638
DOI - 10.1016/j.epag.2016.02.002
Subject(s) - bronchiolitis , immunoglobulin e , medicine , antibody , vitamin , acute bronchiolitis , vitamin d and neurology , pathogenesis , endocrinology , respiratory system , immunology
Vitamin D status has a great effect on respiratory health throughout the lifespan.The aim of this studyThe aim of this study was to estimate and find the relationship between both 25(OH) vitamin D and immunoglobulin E serum levels and bronchiolitis in infancy.MethodsWe quantified serum 25(OH) D and serum immunoglobulin E using (ELISA) in 50 infants with bronchiolitis and 31 healthy controls of matched age and sex.ResultsThe mean serum 25(OH) vitamin D was significantly lower in cases than in controls; it was (12.3±3.9 & 26.2±10.0ng/ml, respectively with p=0.003). The mean serum IgE was significantly higher in cases than in controls; It was (170±66 & 43.8±14.2IU/ml, respectively and p=0.01). Serum IgE showed a non-significant negative correlation with serum 25(OH) vitamin D (r=−0.141, p=>0.05).ConclusionsSerum 25(OH) vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis
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