PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway | Zendy

Xiaozhe Yang | Zendy; Tong Zhao | Zendy; Lin Feng | Zendy; Yanfeng Shi | Zendy; Jinjin Jiang | Zendy; Shuang Liang | Zendy; Baiyang Sun | Zendy; Qing Xu | Zendy; Junchao Duan | Zendy; Zhiwei Sun | Zendy

Open Access

PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway

Author(s) -

Xiaozhe Yang,

Tong Zhao,

Lin Feng,

Yanfeng Shi,

Jinjin Jiang,

Shuang Liang,

Baiyang Sun,

Qing Xu,

Junchao Duan,

Zhiwei Sun

Publication year - 2019

Publication title -

environment international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.582

H-Index - 191

eISSN - 1873-6750

pISSN - 0160-4120

DOI - 10.1016/j.envint.2019.03.057

Subject(s) - dna methylation , pi3k/akt/mtor pathway , cardiotoxicity , epigenetics , apoptosis , protein kinase b , dna damage , cancer research , medicine , microbiology and biotechnology , biology , endocrinology , gene expression , toxicity , dna , genetics , gene

Long-term exposure to fine particulate matter (PM 2.5 ) can causally contribute to progression of atherosclerosis, risk of ischemic heart disease and death, but the underlying mechanism is little known. Since DNA methylation impacts the process of heart disease, it might be useful in exploring potential mechanistic pathways linking PM 2.5 exposure and heart disease.

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