A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis | Zendy

Luca Cardelli | Zendy; Philippa Gardner | Zendy; Ozan Kahramanoğulları | Zendy

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A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis

Author(s) -

Luca Cardelli,

Philippa Gardner,

Ozan Kahramanoğulları

Publication year - 2008

Publication title -

electronic notes in theoretical computer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.242

H-Index - 60

ISSN - 1571-0661

DOI - 10.1016/j.entcs.2007.12.007

Subject(s) - effector , gtp' , microbiology and biotechnology , signalling , context (archaeology) , gtp binding protein regulators , phagocytosis , chemistry , gtpase activating protein , g protein , computer science , computational biology , biology , signal transduction , biochemistry , paleontology , enzyme

At the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner. We present a generic process model for the Rho GTP-binding proteins, and compare it with a previous model that uses ordinary differential equations. We then extend the basic model to include the behaviour of the GDIs. We discuss the challenges this extension brings and directions of further research

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