A Simple Calculus for Proteins and Cells
Author(s) -
Cosimo Laneve,
Fabien Tarissan
Publication year - 2007
Publication title -
electronic notes in theoretical computer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.242
H-Index - 60
ISSN - 1571-0661
DOI - 10.1016/j.entcs.2007.05.013
Subject(s) - simple (philosophy) , domain (mathematical analysis) , process calculus , computer science , sort , semantics (computer science) , calculus (dental) , theoretical computer science , mathematics , programming language , medicine , mathematical analysis , philosophy , dentistry , epistemology , information retrieval
The use of process calculi to represent biological systems has led to the design of different calculi such as brane calculi [Luca Cardelli. Brane calculi. In CMSB, pages 257–278, 2004] and κ-calculus [Vincent Danos and Cosimo Laneve. Formal molecular biology. Theoritical Computer Science, 325(1):69–110, 2004]. Both have proved to be useful to model different types of biological systems.As an attempt to unify the two directions, we introduce the bioκ-calculus, a simple calculus for describing proteins and cells, in which bonds are represented by means of shared names and interactions are modelled at the domain level. Protein-protein interactions have to be at most binary and cell interactions have to fit with sort constraints.We define the semantics of bioκ-calculus, analyse its properties, and discuss its expressiveness by modelling two significant examples: a signalling pathway and a virus infection
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