Open AccessGlomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment
Author(s) -
Nicholas MedjeralThomas,
Hilary Moffitt,
Hannah J. Lomax-Browne,
Nicholas Constantinou,
Tom Cairns,
H. Terence Cook,
Matthew C. Pickering
Publication year - 2019
Publication title -
kidney international reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.225
H-Index - 22
ISSN - 2468-0249
DOI - 10.1016/j.ekir.2019.06.008
Subject(s) - glomerulopathy , medicine , renal function , membranoproliferative glomerulonephritis , factor h , glomerulonephritis , nephropathy , complement system , pathology , complement component 5 , immunology , kidney , endocrinology , antibody , diabetes mellitus
Therapeutic agents that target complement are increasingly available for glomerular diseases. However, the mechanisms linking glomerular complement deposition with inflammation and damage are incompletely understood. Complement factor H-related protein 5 (FHR5) interacts with complement C3 and is considered to promote activation. Circulating and glomerular FHR5 associates with IgA nephropathy and abnormal FHR5 associates with familial C3 glomerulopathy (C3G). We characterized glomerular FHR5 staining in C3G and assessed its relationships with histological features of glomerular injury and clinical outcome.
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