Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass | Zendy

Tamás Radovits | Zendy; Carsten J. Beller | Zendy; John T. Groves | Zendy; Béla Merkely | Zendy; M. Karck | Zendy; Csaba Szabó | Zendy; Gábor Szabó | Zendy

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Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass

Author(s) -

Tamás Radovits,

Carsten J. Beller,

John T. Groves,

Béla Merkely,

M. Karck,

Csaba Szabó,

Gábor Szabó

Publication year - 2012

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.05.056

Subject(s) - peroxynitrite , cardiopulmonary bypass , cardiology , decomposition , catalysis , medicine , ischemia , reperfusion injury , myocardial ischemia , chemistry , pharmacology , biochemistry , enzyme , organic chemistry , superoxide

Peroxynitrite, a toxic nitrogen species, has been implicated in the development of ischemia/reperfusion injury. The aim of the present study was to investigate the effects of the potent peroxynitrite decomposition catalyst, FP15, on myocardial, endothelial, and pulmonary function in an experimental model of cardioplegic arrest and extracorporal circulation.

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