Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1): intramyocardial injection versus scaffold-based application | Zendy

Britta Blumenthal | Zendy; Annika Poppe | Zendy; Peter Golsong | Zendy; Philipp Blanke | Zendy; Bartosz Rylski | Zendy; Friedhelm Beyersdorf | Zendy; Christian Schlensak | Zendy; Matthias Siepe | Zendy

Open Access

Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1): intramyocardial injection versus scaffold-based application

Author(s) -

Britta Blumenthal,

Annika Poppe,

Peter Golsong,

Philipp Blanke,

Bartosz Rylski,

Friedhelm Beyersdorf,

Christian Schlensak,

Matthias Siepe

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.05.026

Subject(s) - medicine , stromal cell , neovascularization , myocardial infarction , transplantation , myocyte , transfection , infarction , cardiology , ischemia , arteriogenesis , angiogenesis , cell culture , biology , genetics

Stromal cell-derived factor-1 (SDF-1) is a potent chemotaxin. Increased SDF-1 levels can be found in ischemic myocardium and might protect against ischemia-reperfusion injury. We hypothesized that transplantation of stem cells overexpressing SDF-1 might improve cardiac function after myocardial infarction (MI). We compared intramyocardial injection with a scaffold-based application of SDF-1-transfected cells.

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