Anticalcification effects of decellularization, solvent, and detoxification treatment for genipin and glutaraldehyde fixation of bovine pericardium | Zendy

HongGook Lim | Zendy; SangHyoun Kim | Zendy; Sun Young Choi | Zendy; Yoon Jun Kim | Zendy

Open Access

Anticalcification effects of decellularization, solvent, and detoxification treatment for genipin and glutaraldehyde fixation of bovine pericardium

Author(s) -

HongGook Lim,

SangHyoun Kim,

Sun Young Choi,

Yoon Jun Kim

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.05.016

Subject(s) - decellularization , genipin , glutaraldehyde , chemistry , calcification , pericardium , biomedical engineering , detoxification (alternative medicine) , fixation (population genetics) , surgery , biochemistry , chromatography , medicine , scaffold , pathology , chitosan , alternative medicine , gene

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve substitutes. The objective of this study was to evaluate the anticalcification effect of decellularization and detoxification in glutaraldehyde (GA)/genipin- and solvent-fixed bovine pericardium using a rabbit intramuscular model which is effective for assessing calcification in bioprosthetic tissue.

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