Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1α are associated with ascending aorta aneurysm size | Zendy

Eric Parietti | Zendy; JeanRené Pallandre | Zendy; Frédéric Deschaseaux | Zendy; Bertrand Aupècle | Zendy; Camille Durst | Zendy; JeanPierre Kantelip | Zendy; Sidney Chocron | Zendy; Siamak Davani | Zendy

Open Access

Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1α are associated with ascending aorta aneurysm size

Author(s) -

Eric Parietti,

JeanRené Pallandre,

Frédéric Deschaseaux,

Bertrand Aupècle,

Camille Durst,

JeanPierre Kantelip,

Sidney Chocron,

Siamak Davani

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.02.065

Subject(s) - aneurysm , medicine , interquartile range , progenitor cell , thoracic aortic aneurysm , ascending aorta , endothelial progenitor cell , cd34 , aortic aneurysm , cardiology , stromal cell , aorta , radiology , stem cell , biology , genetics

Circulating endothelial progenitor cells (EPCs) are a specialized subset of stem/progenitor cells found in bone marrow. They participate in neo-vascularization of injured vessels and predict cardiovascular outcome in patient at risk. Several factors influence their migration and proliferation, among which is the widely studied stromal-derived factor-1α (SDF-1α). In cardiovascular disease, regarding thoracic aortic aneurysms (TAAs), few studies have investigated the levels of EPC and SDF-1α. As rupture, acute dissection and hematoma are acute complications of idiopathic ascending thoracic aortic aneurysm (iATAA) that increase with the size of aneurysm, we aimed to evaluate a potential relationship between circulating EPC and SDF-1α and iATAA size.

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