Effective silencing of adhesion molecules on venous endothelial cells for protection of venous bypass grafts | Zendy

Tobias Walker | Zendy; Isabelle Müller | Zendy; Claudia Raabe | Zendy; Boris Nohé | Zendy; Christof Zanke | Zendy; Gerhard Ziemer | Zendy; Hans-Peter Wendel | Zendy

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Effective silencing of adhesion molecules on venous endothelial cells for protection of venous bypass grafts

Author(s) -

Tobias Walker,

Isabelle Müller,

Claudia Raabe,

Boris Nohé,

Christof Zanke,

Gerhard Ziemer,

Hans-Peter Wendel

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.01.076

Subject(s) - transfection , small interfering rna , cell adhesion molecule , gene silencing , intercellular adhesion molecule 1 , microbiology and biotechnology , adhesion , cell adhesion , medicine , chemistry , biology , biochemistry , gene , organic chemistry

The patency of venous conduits after aortocoronary bypass grafting is still not satisfactory and needs to be improved. Atherosclerotic alterations mediated by adhesion molecules triggering the transmigration of leukocytes are regarded as one of the major causes for venous graft failure. This study deals with short interfering RNA (siRNA)-mediated silencing of adhesion molecule expression on venous endothelial cells, which could lead to a new therapeutic strategy, resulting in improved patency rates by inhibiting early graft alterations.

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