Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆ | Zendy

Nikolaus Pizanis | Zendy; Sebastian Gillner | Zendy; Markus Kamler | Zendy; Herbert de Groot | Zendy; Heinz Jakob | Zendy; Ursula Rauen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

Author(s) -

Nikolaus Pizanis,

Sebastian Gillner,

Markus Kamler,

Herbert de Groot,

Heinz Jakob,

Ursula Rauen

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2011.01.052

Subject(s) - deferoxamine , tbars , propidium iodide , lactate dehydrogenase , chemistry , thiobarbituric acid , lipid peroxidation , cold storage , viability assay , reactive oxygen species , biochemistry , andrology , cell damage , pharmacology , oxidative stress , microbiology and biotechnology , cell , apoptosis , programmed cell death , biology , medicine , enzyme , horticulture

Hypothermia has been shown to lead to cell death via an iron-dependent formation of reactive oxygen species (ROS) in diverse cell types. The susceptibility of lung cells to this injury is unknown - but is of great interest as oxygen is used in lung preservation. Therefore, we studied whether preservation injury to lung epithelial cells can be influenced by iron chelators.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research