Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass☆ | Zendy

Gábor Szabó | Zendy; Leila Seres | Zendy; Pál Soós | Zendy; Matthias Gorenflo | Zendy; Béla Merkely | Zendy; Ferenc Horkay | Zendy; Matthias Karck | Zendy; Tamás Radovits | Zendy

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Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass☆

Author(s) -

Gábor Szabó,

Leila Seres,

Pál Soós,

Matthias Gorenflo,

Béla Merkely,

Ferenc Horkay,

Matthias Karck,

Tamás Radovits

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.12.033

Subject(s) - sodium nitroprusside , cardiopulmonary bypass , medicine , anesthesia , cardiology , vasodilation , cardiac output , tetrahydrobiopterin , cardiac function curve , blood pressure , nitric oxide , nitric oxide synthase , heart failure

Tetrahydrobiopterin (BH4) is an important cofactor of endogenous nitric oxide synthesis. In the present preclinical study, we investigated the effects of BH4 on cardiac and pulmonary function during early reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation.

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