Environmental regulation of valvulogenesis: implications for tissue engineering | Zendy

Paul W. Riem Vis | Zendy; Jolanda Kluin | Zendy; Joost P. G. Sluijter | Zendy; Lex A. van Herwerden | Zendy; Carlijn V. C. Bouten | Zendy

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Environmental regulation of valvulogenesis: implications for tissue engineering

Author(s) -

Paul W. Riem Vis,

Jolanda Kluin,

Joost P. G. Sluijter,

Lex A. van Herwerden,

Carlijn V. C. Bouten

Publication year - 2010

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.05.032

Subject(s) - tissue engineering , biochemical engineering , heart valve , risk analysis (engineering) , computer science , biomedical engineering , engineering , medicine , surgery

Ongoing research efforts aim at improving the creation of tissue-engineered heart valves for in vivo systemic application. Hence, in vitro studies concentrate on optimising culture protocols incorporating biological as well as biophysical stimuli for tissue development. Important lessons can be drawn from valvulogenesis to mimic natural valve development in vitro. Here, we review the up-to-date status of valvulogenesis, focussing on the biomolecular and biophysical regulation of semilunar valve development. In addition, we discuss potential benefits of incorporating concepts derived from valvulogenesis, as well as alternative approaches, in tissue-engineering protocols, to improve in vitro valve development. The combined efforts from clinicians, cell biologists and engineers are required to implement and evaluate these approaches to achieve optimised protocols for heart-valve tissue engineering.

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