Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia–reperfusion injury after cardiopulmonary bypass | Zendy

Tamás Radovits | Zendy; Sevil Korkmaz | Zendy; Christiane Miesel-Gröschel | Zendy; Beatrice Seidel | Zendy; Johannes-Peter Stasch | Zendy; Béla Merkely | Zendy; Matthias Karck | Zendy; Gábor Szabó | Zendy

Open Access

Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia–reperfusion injury after cardiopulmonary bypass

Author(s) -

Tamás Radovits,

Sevil Korkmaz,

Christiane Miesel-Gröschel,

Beatrice Seidel,

Johannes-Peter Stasch,

Béla Merkely,

Matthias Karck,

Gábor Szabó

Publication year - 2010

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.05.025

Subject(s) - medicine , anesthesia , nitric oxide , cardiology , vasodilation , endothelial dysfunction , cardiopulmonary bypass , reperfusion injury , ischemia

Activation of the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) pathway can induce potent cardioprotection-like effects against ischaemia-reperfusion injury and nitro-oxidative stress. We investigated the effects of pharmacological pre-conditioning with Cinaciguat (BAY 58-2667), a novel sGC activator on peroxynitrite-induced endothelial dysfunction in vitro, as well as on myocardial and coronary vascular function during reperfusion in a canine model of cardioplegic arrest and extracorporeal circulation.

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