May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma?☆☆☆ | Zendy

Tommaso Claudio Mineo | Zendy; Vincenzo Ambrogi | Zendy; Maria Elena Cufari | Zendy; Eugenio Pompeo | Zendy

Open Access

May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma?☆☆☆

Author(s) -

Tommaso Claudio Mineo,

Vincenzo Ambrogi,

Maria Elena Cufari,

Eugenio Pompeo

Publication year - 2010

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.02.012

Subject(s) - medicine , extrapleural pneumonectomy , mesothelioma , immunohistochemistry , adjuvant therapy , radiation therapy , oncology , chemotherapy , decortication , pathology , pneumonectomy , lung cancer

The expression of cyclooxygenase-2 (COX-2) and cell-cycle proteins (p21 and p27) proves useful in predicting prognosis and orientating therapy in many malignant tumours. Malignant pleural mesothelioma is an uncommon and lethal cancer for which there are limited treatment options. In this study, we evaluated the impact on prognosis and the influence on therapeutic strategy of immunohistochemical expression of COX-2, p21 and p27 in specimens from patients treated for malignant pleural mesothelioma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research