Aprotinin combined with nitric oxide and prostaglandin E1 protects the canine kidney from cardiopulmonary bypass-induced injury☆☆☆ | Zendy

Lei Du | Zendy; Jing Zhou | Zendy; Jiali Tang | Zendy; Qi An | Zendy; Ke Lin | Zendy; Xiaodong Wu | Zendy; Kaiyu Tao | Zendy; Jin Liu | Zendy

Open Access

Aprotinin combined with nitric oxide and prostaglandin E1 protects the canine kidney from cardiopulmonary bypass-induced injury☆☆☆

Author(s) -

Lei Du,

Jing Zhou,

Jiali Tang,

Qi An,

Ke Lin,

Xiaodong Wu,

Kaiyu Tao,

Jin Liu

Publication year - 2010

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.01.025

Subject(s) - aprotinin , cardiopulmonary bypass , medicine , creatinine , nitric oxide , renal function , platelet activation , anesthesia , platelet , renal blood flow , acute kidney injury , pharmacology

Aprotinin is frequently used to reduce blood loss during cardiac surgery; however, it also causes renal injury. Since aprotinin reduces nitric oxide (NO) and prostaglandin I(2) (PGI(2)), and both cause vasodilation and inhibit activation of neutrophils and platelets, their reduction may be responsible for the injury. This study was to determine whether the combination of aprotinin with NO and prostaglandin E(1) (PGE(1), an analogue of PGI(2)) can attenuate renal injury associated with aprotinin during cardiopulmonary bypass (CPB).

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