The myocardial protective effect of adenosine as an adjunct to intermittent blood cardioplegia during open heart surgery | Zendy

Ruifang Liu | Zendy; Jialin Xing | Zendy; Na Miao | Zendy; Weiran Li | Zendy; Wei Liu | Zendy; Yongqiang Lai | Zendy; Yi Luo | Zendy; Bingyang Ji | Zendy

Open Access

The myocardial protective effect of adenosine as an adjunct to intermittent blood cardioplegia during open heart surgery

Author(s) -

Ruifang Liu,

Jialin Xing,

Na Miao,

Weiran Li,

Wei Liu,

Yongqiang Lai,

Yi Luo,

Bingyang Ji

Publication year - 2009

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2009.06.033

Subject(s) - medicine , troponin i , venous blood , aortic cross clamp , cardiopulmonary bypass , cardiology , creatine , anesthesia , cardiac surgery , clamp , aortic valve replacement , troponin t , myocardial infarction , stenosis , mechanical engineering , clamping , engineering

Although adenosine (ADO) has been shown to have beneficial effects against tissue injury after myocardial ischaemia, the controversy still remains regarding the optimal timing, dose, temperature, method of ADO administration and duration of exposure to the drug. This study investigates the cardioprotective effect of exogenous ADO pretreatment as an adjunct to 1 mmol l(-1) ADO cold (12 degrees C) blood cardioplegia during heart valve replacement surgery.

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