Open AccessCarvedilol may alleviate late cardiac remodelling following surgical ventricular restoration
Author(s) -
Eiichi Yoshikawa,
Akira Marui,
Masaki Tsukashita,
Tomohiro Nishina,
Jian Wang,
Hiroyuki Muranaka,
Tadashi Ikeda,
Masashi Komeda
Publication year - 2009
Publication title -
european journal of cardio-thoracic surgery
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1016/j.ejcts.2009.04.072
Subject(s) - carvedilol , medicine , cardiology , diastole , ventricular remodeling , myocardial infarction , cardiac function curve , ligation , blood pressure , heart failure
Surgical ventricular restoration (SVR) can be effective to treat ischaemic cardiomyopathy or left ventricular (LV) aneurysm. However, the initial improvement in LV function does not always last long because of LV remodelling. Beta-blockers prevent LV remodelling of failing hearts; however, their effects following SVR have not been elucidated. Thus, we sought to investigate the effects of a potent beta-blocker, carvedilol, on LV remodelling and function following SVR in rats with myocardial infarction.