Endogenous stem cells in patients undergoing coronary artery bypass graft surgery | Zendy

Olena Dotsenko | Zendy; Marjan Jahangiri | Zendy

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Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Author(s) -

Olena Dotsenko,

Marjan Jahangiri

Publication year - 2009

Publication title -

european journal of cardio-thoracic surgery

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2009.04.002

Subject(s) - stem cell , medicine , endogeny , coronary artery disease , observational study , clinical significance , artery , coronary artery bypass surgery , regeneration (biology) , cardiac surgery , cardiology , surgery , genetics , biology , microbiology and biotechnology

Considerable research efforts have recently been made towards the application of autologous stem cell therapy for cardiovascular regeneration. Patients with coronary artery disease undergoing surgery represent a potential target. As yet, this approach has failed to obtain satisfactory evidence in clinical studies. However, several observational studies have described mobilising effect of cardiac surgery on endogenous stem cells, although the mechanisms of this phenomenon and its clinical relevance are not defined. This article reviews available clinical data on the effect of cardiac surgery on endogenous stem cells and outlines some of the controversies in this area.

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