Addition of dextran sulfate to blood cardioplegia attenuates reperfusion injury in a porcine model of cardiopulmonary bypass☆ | Zendy

Yara Banz | Zendy; Robert Rieben | Zendy; Claudia Zobrist | Zendy; Pascal Meier | Zendy; Sidney Shaw | Zendy; Jonas Lanz | Zendy; Thierry Carrel | Zendy; Pascal Berdat | Zendy

Open Access

Addition of dextran sulfate to blood cardioplegia attenuates reperfusion injury in a porcine model of cardiopulmonary bypass☆

Author(s) -

Yara Banz,

Robert Rieben,

Claudia Zobrist,

Pascal Meier,

Sidney Shaw,

Jonas Lanz,

Thierry Carrel,

Pascal Berdat

Publication year - 2008

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2008.05.024

Subject(s) - cardiopulmonary bypass , dextran , medicine , anesthesia , cardiology , reperfusion injury , chemistry , ischemia , biochemistry

Contact of blood with artificial surfaces and air as well as ischemia/reperfusion injury to the heart and lungs mediate systemic and local inflammation during cardiopulmonary bypass (CPB). Activation of complement and coagulation cascades leads to and accompanies endothelial cell damage. Therefore, endothelial-targeted cytoprotection with the complement inhibitor and endothelial protectant dextran sulfate (DXS, MW 5000) may attenuate CBP-associated myocardial and pulmonary injury.

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