Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures☆ | Zendy

Stefano Elia | Zendy; Renato Massoud | Zendy; Gianluca Guggino | Zendy; Benedetto Cristino | Zendy; Claudio Cortese | Zendy; Alessia Raffaella De Massimi | Zendy; R Zenobi | Zendy

Open Access

Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures☆

Author(s) -

Stefano Elia,

Renato Massoud,

Gianluca Guggino,

Benedetto Cristino,

Claudio Cortese,

Alessia Raffaella De Massimi,

R Zenobi

Publication year - 2008

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2008.01.014

Subject(s) - medicine , pleural effusion , malignancy , pleural fluid , false positive paradox , tumor marker , cancer , pathology , malignant pleural effusion , effusion , gastroenterology , surgery , machine learning , computer science

Pleural effusion is a common diagnostic problem and a challenge to the thoracic surgeon. The analysis of serum and body fluids for tumor markers is an established diagnostic procedure. Among various markers, tumors are linked to the overexpression of a glycolytic isoenzyme, M2-pyruvate-kinase (M2-PK). This preliminary study evaluated this enzyme as a tumor marker to differentiate malignant from benign pleural effusion.

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