PTEN expression is a strong predictor of survival in mesothelioma patients☆ | Zendy

Isabelle Opitz | Zendy; Alex Soltermann | Zendy; Martin Abaecherli | Zendy; Marc Hinterberger | Zendy; Nicole ProbstHensch | Zendy; Rolf A. Stahel | Zendy; Holger Moch | Zendy; Walter Weder | Zendy

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PTEN expression is a strong predictor of survival in mesothelioma patients☆

Author(s) -

Isabelle Opitz,

Alex Soltermann,

Martin Abaecherli,

Marc Hinterberger,

Nicole ProbstHensch,

Rolf A. Stahel,

Holger Moch,

Walter Weder

Publication year - 2008

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.09.045

Subject(s) - pten , tensin , mesothelioma , immunohistochemistry , cancer research , tumor suppressor gene , medicine , tissue microarray , biomarker , oncology , cancer , biology , pi3k/akt/mtor pathway , pathology , carcinogenesis , signal transduction , biochemistry

Malignant pleural mesothelioma (MPM) is a highly aggressive tumour with poor prognosis and limited response to therapy. MPM is characterised by complex chromosomal aberrations, including chromosome 10 losses. The tumour suppressor gene phosphatase and tensin homologue deleted from chromosome 10 (PTEN) located on chromosome 10q23 plays an important role in different cancer, but its relevance for MPM is unclear.

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