Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats☆ | Zendy

Hideo Kanemitsu | Zendy; Shinji Takaı̈ | Zendy; Hiroshi Tsuneyoshi | Zendy; Eiji Yoshikawa | Zendy; Tomohiro Nishina | Zendy; Mizuo Miyazaki | Zendy; Tadashi Ikeda | Zendy; M Komeda | Zendy

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Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats☆

Author(s) -

Hideo Kanemitsu,

Shinji Takaı̈,

Hiroshi Tsuneyoshi,

Eiji Yoshikawa,

Tomohiro Nishina,

Mizuo Miyazaki,

Tadashi Ikeda,

M Komeda

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.09.040

Subject(s) - chymase , medicine , cardiology , ventricular remodeling , fibrosis , myocardial fibrosis , cardiac function curve , ventricular pressure , heart failure , blood pressure , endocrinology , mast cell , immunology

Although left ventricular repair (LVR) has been widely performed, the initial improvement of LV function does not last because of LV remodeling. Recent studies have demonstrated that chymase, a local enzyme in the heart, promotes angiotensin II formation as well as activation of transforming growth factor (TGF)-beta, both of which facilitate myocardial fibrosis. Therefore, chymase blockade may play an important role in the prevention of cardiac remodeling after LVR. In this study, the effects of chronic chymase inhibition (Chy-I) after LVR were evaluated in a rat LV aneurysm model.

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