Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation | Zendy

Hideaki Mori | Zendy; Itaru Nagahiro | Zendy; Tomohiko Osaragi | Zendy; Kazutoshi Kotani | Zendy; H Nakanishi | Zendy; Yoshifumi Sano | Zendy; Hiroshi Date | Zendy; Nobuyoshi Shimizu | Zendy

Open Access

Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation

Author(s) -

Hideaki Mori,

Itaru Nagahiro,

Tomohiko Osaragi,

Kazutoshi Kotani,

H Nakanishi,

Yoshifumi Sano,

Hiroshi Date,

Nobuyoshi Shimizu

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.07.017

Subject(s) - lung , lung transplantation , neutrophil elastase , flushing , elastase , medicine , reperfusion injury , transplantation , pharmacology , chemistry , immunology , ischemia , inflammation , endocrinology , biochemistry , enzyme

Neutrophil elastase plays an important role in ischemia-reperfusion injury. We hypothesized that the addition of sivelestat, a specific neutrophil elastase inhibitor, to the organ flushing solution would decrease reperfusion injury in a rat single left-lung transplant model.

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