Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebo-controlled study | Zendy

Massimo Meco | Zendy; Silvia Cirri | Zendy; Chiara Gallazzi | Zendy; Giulia Magnani | Zendy; Daniele Cosseta | Zendy

Open Access

Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebo-controlled study

Author(s) -

Massimo Meco,

Silvia Cirri,

Chiara Gallazzi,

Giulia Magnani,

Daniele Cosseta

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.05.005

Subject(s) - double blinded , desflurane , medicine , placebo , coronary artery bypass surgery , anesthesia , artery , bypass surgery , ischemic preconditioning , cardiology , ischemia , propofol , alternative medicine , pathology

Recent clinical and experimental data indicate that volatile anaesthetics may precondition myocardium against ischaemia and infarction. The present clinical trial was designed to verify the cardioprotective effects of desflurane in patients undergoing elective coronary artery bypass surgery. It was hypothesized that desflurane preconditioning would decrease postoperative release of troponin I and brain natriuretic peptide (NT-proBNP). Besides, we have hypothesized that desflurane preconditioning would preserve the myocardium from the dysfunction following cardioplegic arrest.

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