Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass | Zendy

Gábor Veres | Zendy; Tamás Radovits | Zendy; Holger Schultz | Zendy; Li-ni Lin | Zendy; Joachim Hütter | Zendy; Ernst Weigang | Zendy; Zoltán Szabolcs | Zendy; Gábor Szabó | Zendy

Open Access

Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass

Author(s) -

Gábor Veres,

Tamás Radovits,

Holger Schultz,

Li-ni Lin,

Joachim Hütter,

Ernst Weigang,

Zoltán Szabolcs,

Gábor Szabó

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.02.039

Subject(s) - aprotinin , cardiopulmonary bypass , sodium nitroprusside , medicine , bradykinin , anesthesia , pharmacology , cardiology , nitric oxide , receptor

Aprotinin is a widely used serine protease inhibitor during cardiopulmonary bypass to reduce blood loss and preserve platelet function. However, the bovine-derived aprotinin can induce hypersensitivity reaction with fatal complications. Furthermore, vascular effects of aprotinin are not completely elucidated. The current study is designed to investigate the effects of recently developed recombinant aprotinin on blood loss and coronary vascular function in a clinically relevant canine model of cardiopulmonary bypass without aortic cross-clamping and cardioplegia.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research