Brain oxygen and metabolism is dependent on the rate of low-flow cardiopulmonary bypass following circulatory arrest in newborn piglets☆ | Zendy

Peter Pastuszko | Zendy; Huiping Liu | Zendy; Alberto Mendoza-Paredes | Zendy; Steven Schultz | Zendy; Scott D. Markowitz | Zendy; William J. Greeley | Zendy; David F. Wilson | Zendy; Anna Pastuszko | Zendy

Open Access

Brain oxygen and metabolism is dependent on the rate of low-flow cardiopulmonary bypass following circulatory arrest in newborn piglets☆

Author(s) -

Peter Pastuszko,

Huiping Liu,

Alberto Mendoza-Paredes,

Steven Schultz,

Scott D. Markowitz,

William J. Greeley,

David F. Wilson,

Anna Pastuszko

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.01.049

Subject(s) - cardiopulmonary bypass , microdialysis , creb , protein kinase b , circulatory system , anesthesia , deep hypothermic circulatory arrest , chemistry , hypothermia , perfusion , medicine , phosphorylation , endocrinology , cerebral blood flow , cerebral perfusion pressure , central nervous system , biochemistry , transcription factor , gene

To determine the optimum rate of low-flow hypothermic cardiopulmonary bypass (LF), following circulatory arrest (DHCA) on brain oxygenation (bO(2)), extracellular dopamine (DA), phosphorylation of select neuroregulatory proteins responsible for neuronal injury, and survival following ischemic brain injury: CREB, Erk1/2, Akt, Bcl-2, and Bax.

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