Mechanical restitution curves — a possible load independent assessment of contractile function | Zendy

Knut E. Kjørstad | Zendy; Dag Nordhaug | Zendy; Christian Korvald | Zendy; Stig Müller | Zendy; Tor Steensrud | Zendy; Truls Myrmel | Zendy

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Mechanical restitution curves — a possible load independent assessment of contractile function

Author(s) -

Knut E. Kjørstad,

Dag Nordhaug,

Christian Korvald,

Stig Müller,

Tor Steensrud,

Truls Myrmel

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2007.01.013

Subject(s) - preload , afterload , cardiology , medicine , hemodynamics , stroke volume , blood pressure , anesthesia , heart rate

The time constant of mechanical restitution (T((MRC))), proposed to reflect changes in calcium release and uptake, has been shown to increase in left ventricular (LV) failure, and might have a potential as an index of contractile function. However, in vivo studies of the effect on T((MRC)) of changing loading conditions in the normal and failing heart have not been reported. Consequently, in this study, we tested the hypothesis that the increase in T((MRC)) in vivo is independent of preload and afterload.

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