Non-cultured cell transplantation in an ovine model of non-ischemic heart failure | Zendy

Nicolas Borenstein | Zendy; Valérie Chetboul | Zendy; Patrick Bruneval | Zendy; Mehrak Hekmati | Zendy; Renaud Tissier | Zendy; L. Behr | Zendy; Geneviève Dérumeaux | Zendy; Didier Montarras | Zendy

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Non-cultured cell transplantation in an ovine model of non-ischemic heart failure

Author(s) -

Nicolas Borenstein,

Valérie Chetboul,

Patrick Bruneval,

Mehrak Hekmati,

Renaud Tissier,

L. Behr,

Geneviève Dérumeaux,

Didier Montarras

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.12.023

Subject(s) - transplantation , medicine , skeletal muscle , heart failure , heart transplantation , thoracotomy , cardiomyopathy , ischemic cardiomyopathy , myocyte , ejection fraction , cardiology , pathology , surgery

Cell therapy may be a promising alternative or adjunct to current treatment modalities for ischemic heart failure. But little is known on the impact of myogenic cell transplantation in large animal models of non-ischemic cardiomyopathy. The aim of the present study was to explore whether an ovine model of toxin-induced heart disease could benefit from non-cultured skeletal muscle cell transplantation.

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